Category Archives: Cardiology

How Frequently Is Venous Thromboembolism in Heparin-Treated Patients Associated With Heparin-Induced Thrombocytopenia? Conclusion

For example, although generally similar working definitions for HIT based on platelet count changes were used in the studies, different confirmatory tests were used that are known to vary in their sensitivity and specificity for HIT. Although patients remain at … Continue reading

How Frequently Is Venous Thromboembolism in Heparin-Treated Patients Associated With Heparin-Induced Thrombocytopenia? Discussion

Each year, an estimated 2 million Americans acquire deep venous thrombosis and 600,000 acquire pulmonary embolism. Many of these patients will receive heparin, which is routinely initiated (often in the emergency department) for treatment of VTE, yet is potentially catastrophic … Continue reading

How Frequently Is Venous Thromboembolism in Heparin-Treated Patients Associated With Heparin-Induced Thrombocytopenia? Frequency Estimates

HIT was prospectively defined in the studies, typically as a platelet count < 100 X 109/L or a 40 to 50% decrease in count, with serologic confirmation (Table 2). Thrombocytopenia without laboratory confirmation of heparin-dependent antibody was not considered HIT … Continue reading

How Frequently Is Venous Thromboembolism in Heparin-Treated Patients Associated With Heparin-Induced Thrombocytopenia? Data Set

From 41 possibly relevant articles identified from the literature database search, we found 9 articles involving eight clinical studies that met inclusion criteria for our analysis. The remaining 32 articles failed to meet one or more inclusion criteria, most often … Continue reading

How Frequently Is Venous Thromboembolism in Heparin-Treated Patients Associated With Heparin-Induced Thrombocytopenia? Literature Search

To identify potentially relevant articles, a search was performed using the Medline database (November 1984 to November 2004) and the Cochrane Library (The Cochrane Library 2004, issue 4) and the search terms “heparin-induced thrombocytopenia” or “heparin-associated thrombocytopenia” together with “thrombosis” … Continue reading

How Frequently Is Venous Thromboembolism in Heparin-Treated Patients Associated With Heparin-Induced Thrombocytopenia?

Infractionated heparin and low-molecular-weight heparins (LMWHs) are routinely used for thromboprophylaxis or treatment. Despite heparin therapy, patients sometimes have new or recurrent thrombosis if anticoagulation fails or heparin-induced thrombocytopenia (HIT) occurs. HIT is a serious, immune-mediated condition in which 38 … Continue reading

A Characteristic Change in Ventilation Mode During Exertional Dyspnea in Patients With Chronic Heart Failure: Comment

Although the pulmonary wedge pressure was not measured in this study, this dose of isosorbide dinitrate has been demonstrated to selectively decrease the filling pressure during exercise in patients with chronic heart failure Indeed, peak exercise heart rate and systolic … Continue reading

A Characteristic Change in Ventilation Mode During Exertional Dyspnea in Patients With Chronic Heart Failure: Conclusion

However, this hypothesis is not consistent with the findings presented herein, as decreases in the anaerobic threshold and exercise ventilatory efficiency, ie, an increased ventilatory equivalent for carbon dioxide, were not different in patients with and without exertional dyspnea. Furthermore, … Continue reading

A Characteristic Change in Ventilation Mode During Exertional Dyspnea in Patients With Chronic Heart Failure: Discussion

However, serial changes in the ventilation mode have not been studied in order to characterize exertional dyspnea. In this study, we disclosed that the ventilation mode undergoes a dynamic change during exertional dyspnea in patients with chronic heart failure. The … Continue reading

A Characteristic Change in Ventilation Mode During Exertional Dyspnea in Patients With Chronic Heart Failure: Effect of Isosorbide Dinitrate

The effect of isosorbide dinitrate was examined in 17 patients in group A who showed the abnormal VT-f relationship during exertional dyspnea. Exertional dyspnea disappeared with isosorbide dinitrate in five patients, and the onset delayed for 1 min or more … Continue reading