Category Archives: Cell

Macrophages, Cell Proliferation: DISCUSSION(6)

No clear relationship between proliferative activity and macrophages was found. Although the data of this study do not lead us to discard a possible role for macrophages in the proliferative activity of luteal cells at the end of the early … Continue reading

Macrophages, Cell Proliferation: DISCUSSION(5)

In the present study, stromal (mainly vascular) cells comprise the majority of proliferating cells in the CL, which agrees with previous studies in human and nonhuman primates. However, this study demonstrated for the first time that about 5% of GLC … Continue reading

Macrophages, Cell Proliferation: DISCUSSION(4)

Otherwise, several lines of evidence suggest that macrophages are also involved in the luteolytic process in many species. Although this study does not preclude the existence of a possible role for macrophages during structural luteolysis in subsequent cycles, these data … Continue reading

Macrophages, Cell Proliferation: DISCUSSION(3)

The invasion of the newly formed CL by macrophages is most likely due to the release of chemotactic factors by GLC. In the rat, the expression of a chemotactic factor, monocyte chemoat-tractant protein-1 (MCP-1), has recently been reported. In the … Continue reading

Macrophages, Cell Proliferation: DISCUSSION(2)

Morphological luteinization (increase in cell size as a consequence of the accumulation of smooth endoplasmic reticulum and mitochondria) is completed by Days 18-19, which is evidenced by the clear morphological differences existing from this time onward between TLC and GLC, … Continue reading

Macrophages, Cell Proliferation: DISCUSSION(1)

The existence of possible roles for macrophage-derived factors in ovarian physiology has been widely considered during the last few years, since cumulative data indicate the existence of a bidirectional communication between immune and endocrine systems (reviewed in ). In this … Continue reading

Macrophages, Cell Proliferation: RESULTS(4)

Quantitative data are presented in Figure 6 and Table 1. The densities of Ki67+ and mitotic cells were parallel. Densities were very high during the early luteal phase and showed significant decreases at midluteal and late luteal phases. In the … Continue reading

Macrophages, Cell Proliferation: RESULTS(3)

Similar changes were observed when the number of macrophages was expressed with respect to the number of GLC (to avoid the appearance of changes in the density of macrophages due to the changes in the volume occupied by the cytoplasm … Continue reading

Macrophages, Cell Proliferation: RESULTS(2)

On Days 25-27, regressive changes were evident in the CL. Isolated GLC showed extreme vacuolization of the cytoplasm and expression of CD68 immunoreactivity (Fig. 2L). These CD68+ GLC were clearly distinguished from macrophages because they showed large round nuclei, vacuolated … Continue reading

Macrophages, Cell Proliferation: RESULTS(1)

Macrophages On Day 14 (day of ovulation), the ruptured follicles showed variable features. In some cases, macrophages were exclusively found among the theca cells, whereas in others, some macrophages had invaded the granulosa cell layer. On Days 15 and 16 … Continue reading