Category Archives: Dismutase

Aerosolization of Superoxide Dismutase: Conclusion

Evidence for an increased ELF 02x burden compared to normal individuals has been shown in several human lung disorders, including cystic fibrosis, idiopathic pulmonary fibrosis, interstitial pulmonary diseases associated with the collagen vascular disorders, inorganic dust diseases, cigarette smoking, human … Continue reading

Aerosolization of Superoxide Dismutase: Discussion

As was observed in vitrv, aerosolization in vivo was associated with the maintenance of activity of the SOD that impacted on the epithelial surface (Fig 3). The pattern of anti-02A capacity in ELF increased and declined in a parallel fashion … Continue reading

Aerosolization of Superoxide Dismutase: Results

Experimental Model To evaluate the feasibility of aerosolizing rSOD to a large experimental animal, rSOD was aerosolized to sheep, and broncho-alveolar lavage used to recover ELF before and after aerosolization. Briefly, female mixed-breed sheep (total n = 12; mean weight, … Continue reading

Aerosolization of Superoxide Dismutase: Materials and Methods

Progressive damage to the respiratory epithelium is a prominent feature of a variety of acute and chronic inflammatory pulmonary diseases. In many of these disorders, particularly those characterized by large numbers of activated alveolar macrophages, neutrophils, or eosinophils in respiratory … Continue reading