Category Archives: Hepatitis B

Reactivation of hepatitis B e antigen-negative chronic hepatitis B in a bone marrow transplant recipient following lamivudine withdrawal: DISCUSSION Part 3

Alternatively, the discontinuation of immunosuppression may have contributed to our patient’s reactivation hepatitis. It is conceivable that the withdrawal of immunosuppression, in association with the cessation of antiviral therapy, led to the restoration of immunocompetence followed by immune-mediated cytolysis of … Continue reading

Reactivation of hepatitis B e antigen-negative chronic hepatitis B in a bone marrow transplant recipient following lamivudine withdrawal: DISCUSSION Part 2

The patient described remained persistently HBeAg-negative and anti-HBe-positive before and during therapy with lamivudine. During this time, he had normal aminotransferase levels and negative HBV DNA. Because this profile traditionally signifies the absence of viral replication and represents the end … Continue reading

Reactivation of hepatitis B e antigen-negative chronic hepatitis B in a bone marrow transplant recipient following lamivudine withdrawal: DISCUSSION Part 1

The development of the nucleoside analogue lamivudine has revolutionized the management of chronic HBV infection. Large, randomized trials have confirmed its efficacy in the treatment of both HBeAg-positive and HBeAg-negative HBV-infected patients, as well as in the prophylaxis of HBV … Continue reading

Reactivation of hepatitis B e antigen-negative chronic hepatitis B in a bone marrow transplant recipient following lamivudine withdrawal: CASE PRESENTATION Part 2

The patient’s cyclosporine and prednisone doses were gradually tapered. He was re-evaluated in April 2000, at which point he was off all immunosuppression, but continued lamivudine and ursodeoxycholic acid therapy. Although he denied symptoms suggestive of liver disease, the patient … Continue reading

Reactivation of hepatitis B e antigen-negative chronic hepatitis B in a bone marrow transplant recipient following lamivudine withdrawal: CASE PRESENTATION Part 1

A 32-year-old Somalian man was evaluated in January 2000 for HBeAg-negative, anti-HBe-positive, chronic HBV infection. The patient had a history of idiopathic hyper-eosinophilic syndrome, which had responded suboptimally to corticosteroids, hydroxyurea and interferon-alpha; he was being considered for BMT. He … Continue reading

Reactivation of hepatitis B e antigen-negative chronic hepatitis B in a bone marrow transplant recipient following lamivudine withdrawal

Reactivation of the hepatitis B virus (HBV) is a well recognized complication of immunosuppression, including that due to cytotoxic chemotherapy, corticosteroid administration and organ transplantation. Bone marrow transplantation (BMT) is one such situation in which serious, occasionally fatal, flares of … Continue reading