Category Archives: Neonatal-perinatal medicine

Evaluation of care in neonatal-perinatal medicine:THE INTERVENTION (part 1)

Theory, as well as animal studies, may suggest advantages of a new therapy compared with conventional methods. However, theory and observation often yield differing results. The validity of animal models of neonatal respiratory failure is arguable. Evidence of benefit for … Continue reading

Evaluation of care in neonatal-perinatal medicine:THE INTERVENTION (part 4)

New methods of data presentation and analysis have recently been proposed. These techniques present data range and distribution of data as confidence intervals rather than standard deviations, and differences between the groups are expressed as a single value for the … Continue reading

Evaluation of care in neonatal-perinatal medicine:THE COST (part 1)

Convincing evidence of clinical benefit is a key initial criterion in the assessment of any new technology in medical practice. Clinical availability, details of the ‘learning curve’, which is inevitable for all highly technical skills, and consistency of outcome are … Continue reading

Evaluation of care in neonatal-perinatal medicine:SUMMARY

Important requirements should be met before common acceptance of new therapies. The following recommendations for introduction of a new therapy are based on a review of the current information. 1. The magnitude of baseline risk without treatment should be known … Continue reading

Evaluation of care in neonatal-perinatal medicine:THE COST (part 2)

Before the introduction of high frequency ventilation as a treatment in many neonatal intensive care units, the magnitude of baseline risk was well known. Because the risk from conventional therapy was felt to be serious (death or chronic lung disease) … Continue reading

Evaluation of care in neonatal-perinatal medicine:THE INTERVENTION (part 3)

These studies used ‘standard’ methods of data presentation and analysis. Outcomes for two treatments were calculated and compared. The likelihood that differences found were simply due to random chance or that there was a ‘real’ or ‘significant’ difference between treatment … Continue reading

Evaluation of care in neonatal-perinatal medicine:THE INTERVENTION (part 2)

Studies may also provide conflicting evidence of both benefit and harm for the baby. This may be for a variety of reasons including differences in study design, study population, implementation of the intervention, cointerventions affecting the same outcomes, and differences … Continue reading

Evaluation of care in neonatal-perinatal medicine: part 2 – birth control alesse

The risks and pitfalls of implementing biomedical technology have been reported. The intent here is to examine the introduction of methods of neonatal and perinatal care. High frequency ventilation may serve as an example of how to use these new … Continue reading

Evaluation of care in neonatal-perinatal medicine: part 1

  With the introduction of potential advances in perinatal-neonatal care, essential questions need to be asked as claims of benefit from new treatments are examined. Minimum assessments should include the following: • The magnitude of the baseline risk: What is … Continue reading