Category Archives: Nonalcoholic steatohepatitis

Nonalcoholic steatohepatitis in nondiabetic obese patients: PATIENTS AND METHODS Part 2

The remaining 44 patients underwent the following laboratory tests: blood count, platelet count, bilirubin level, ALT level, AST level, alkaline phosphatase level, gamma-glutamyl transpeptidase level, prothrombin time, serum protein electrophoresis, serum iron level, ferritin level, transferrin saturation, ceruloplasmin level and … Continue reading

Nonalcoholic steatohepatitis in nondiabetic obese patients: DISCUSSION Part 3

Wanless and Lentz reported an apparent positive association between degree of obesity and severity of histological findings. However, when the authors considered only obese patients without diabetes mellitus, this association was not verified. This finding suggests that diabetes mellitus, rather … Continue reading

Nonalcoholic steatohepatitis in nondiabetic obese patients: DISCUSSION Part 2

Although the histological criteria for the diagnosis of NASH vary in different studies, it is usually diagnosed by the presence of alcoholic hepatitis-like histological patterns in nonalcoholic individuals. In the present study, the minimal criterion for the diagnosis of NASH … Continue reading

Nonalcoholic steatohepatitis in nondiabetic obese patients: DISCUSSION Part 1

Obesity is a major public health problem in western countries, and it has long been correlated with hepatic alterations, especially steatosis. More recently, special attention has been devoted to the presence of more severe lesions associated with steatosis in obese … Continue reading

Nonalcoholic steatohepatitis in nondiabetic obese patients: RESULTS

Of the 912 patients examined, 33 underwent liver biopsy. Four patients were excluded because they had steatosis only. As a result, 29 fulfilled the histological criteria established for the diagnosis of NASH (3.18%; 95% CI 2.2 to 4.6). Of these … Continue reading

Nonalcoholic steatohepatitis in nondiabetic obese patients: PATIENTS AND METHODS Part 3

Steatosis was considered mild when it involved one-third of the hepatic lobule, moderate when it involved one-to two-thirds of the hepatic lobule, and severe when it involved more than two-thirds of the hepatic lobule. The lobular inflammatory infiltrate was also … Continue reading

Nonalcoholic steatohepatitis in nondiabetic obese patients: PATIENTS AND METHODS Part 1

A prospective study was conducted in 912 consecutive obese patients seen at the Nutrition and Gastroenterology Outpatient Clinic at Irmandade Santa Casa de Misericordia, Porto Alegre, Brazil, during a period of three years (1997 to 1999). Patients sought the clinic … Continue reading

Nonalcoholic steatohepatitis in nondiabetic obese patients

In the late 1970s, Schaffner and Adler studied obese people with no history of excessive alcohol consumption and observed histological findings in the liver similar to those found in alcoholic patients. The term ‘nonalcoholic steatohepatitis’ (NASH) was first used in … Continue reading