Category Archives: Pharmacodynamics

Advances in the pharmacotherapy: PHARMACOTHERAPY OF BEHAVIOURAL DISORDERS IN DEMENTIA(4)

Despite lack of compelling evidence, neuroleptics remain first line intreating behavioural problems in dementia. Recommendations involve starting at a low dose and increasing slowly until efficacy is observed or until side effects emerge. Neuroleptics have been associated with various side … Continue reading

Pharmacodynamics and alternative antimicrobial dosing regimens: part 3

Another important observation is that, with the exception of endocarditis and perhaps meningitis, no additional benefits are seen with extremely high concentrations of beta-1 actams. The relevant impact of these findings to the practising clinician is that the large multigram … Continue reading

Pharmacodynamics and alternative antimicrobial dosing regimens: part 1

MANY YEARS HAVE PASSED SINCE THE DISCOVERY OF PENICIL-lin by Fleming in 1929 and, although many other antimicrobials have since been discovered, the debate regarding optimal doses and dosing regimens continues. Antimicrobial therapy is unique in many respects since the … Continue reading

Pharmacodynamics and alternative antimicrobial dosing regimens: part 2

During the past decade factors governing the pharmacokinetic paiameters of aniimicrobials (disiribution into tissues, free versus bound antimicrobials, effect of dosage on half-life) have been further clarified and attention has shifted towards new pharmacodynamic parameters other than the traditional in … Continue reading