Category Archives: Rat Testicular

Immunoregulatory Activity in Adult Rat Testicular: DISCUSSION(5)

Finally, the present data indicate that expression of Fas ligand, a cytotoxic regulator of T cells, on the Sertoli cells in the seminiferous tubule compartment of the testis is not able to prevent T-cell access to the interstitial tissue compartment. … Continue reading

Immunoregulatory Activity in Adult Rat Testicular: DISCUSSION(4)

Overall, the levels of inhibitory activity were inversely related to IF volume, suggesting that reduction of IF volume in the presence of a constant secretion of the inhibitory factor may have been responsible for the changes in inhibitor levels in … Continue reading

Immunoregulatory Activity in Adult Rat Testicular: DISCUSSION(3)

The reasons for the changes in T-cell numbers in this experimental model remain to be established, although it appears likely that the T cells may be responding to alterations in the number and activity of the testicular macrophages. These data … Continue reading

Immunoregulatory Activity in Adult Rat Testicular: DISCUSSION(2)

These data apply specifically to the interstitial tissue parenchyma surrounding the seminiferous tubules. The sampling method did not include the mediastinum or rete testis, while the contribution of the testicular capsule to the reference volume was reduced due to frequent … Continue reading

Immunoregulatory Activity in Adult Rat Testicular: DISCUSSION(1)

Previous studies on T cells and their subsets in the normal rat testicular interstitium have used proportional estimates (i.e., values expressed as a ratio, areal density, or proportion of another testicular cell or compartment), and have been limited by the … Continue reading

Immunoregulatory Activity in Adult Rat Testicular: RESULTS(6)

The levels of activity had returned to normal by 21 days after EDS treatment in both groups, regardless of the presence of T-im-plants and differences in circulating gonadotropin levels and functional Leydig cells. Correlation of Leukocytes and T Cell-Inhibiting Activity after … Continue reading

Immunoregulatory Activity in Adult Rat Testicular: RESULTS(5)

The pattern of changes in total CD4+ cells (T cells and macrophages) after EDS treatment was quite different from the changes in T-cell numbers. Following EDS treatment, CD4+ cells increased more than 2-fold in the presence or absence of T-implants … Continue reading

Immunoregulatory Activity in Adult Rat Testicular: RESULTS(4)

Testicular CD8 and CD4 Subsets after EDS Treatment At 3 days and 10 days after EDS treatment with or without s.c. T-implants, there was a significant increase in CD8+ T cells to almost double the numbers in the DMSO-treated controls, … Continue reading

Immunoregulatory Activity in Adult Rat Testicular: RESULTS(3)

Testicular CD8 and CD4 Subsets after DMSO Vehicle Injection At 3 days after treatment with the DMSO vehicle alone, the number of CD8+ T cells increased by 53% (Fig. 2A), although this was not reflected by an increase in the … Continue reading

Immunoregulatory Activity in Adult Rat Testicular: RESULTS(2)

In the normal testes, the number of CD8+ cells was calculated to be 0.56 ± 0.05 X 106 cells per testis (mean ± SEM, n = 6). By contrast, the number of CD4+ cells was 5.8 ± 0.3 X 106 … Continue reading