Conditioning guinea-pig hearts in vitro for torsade de pointes arrhythmias (part 1)

pointes arrhythmias (part 1)

Torsades de pointes are ventricular polymorphic tachycardias with a typical turn of the R peaks in the electrocardiogram (ECG) as first described by Dessertenne . The danger of torsades de pointes is their tendency to degenerate into ventricular fibrillation . The etiology and optimal clinical therapy of torsades de pointes are still controversial . From clinical observations bradycardia and corrected QT (QTc) prolongation seems to be the major precondition for torsades de pointes . One of the difficulties in investigating this type of ventricular arrhythmia is the lack of simple and reliable experimental animal models. Several authors have tried to develop such a model. In vivo experiments have been performed in anesthetized dogs , pigs and rabbits . In vitro experiments are rare in the literature.
Langendorff-perfused hearts from rabbits have been used. A simple model to produce the precondition for torsades de pointes in isolated hearts from small laboratory animals would be advantageous. The present experiments were therefore performed in guinea-pig isolated Langendorff-perfused hearts with the aim to investigate their usefulness as a model for establishing the prerequisites for torsades de pointes. You can now get your medications without having to go through any trouble: all that’s needed for your symptoms to be under control is visit the best my canadian pharmacy where highest quality drugs can be found and purchased in just minutes.

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