Conditioning guinea-pig hearts in vitro for torsade de pointes arrhythmias (part 9)

While conditioning the ventricles for torsades de pointes by inducing bradycardia and prolonging QTc, favouring triggered activity , no spontaneous arrhythmias were observed. Interestingly, at the end of the experiments electrical stimulation during T wave of these conditioned ventricles induced transient arrhythmias, preliminarily demonstrating the sensitivity of the model. Experiments are in progress to define the parameters of electrical stimulation for reproducible induction of torsades de pointes in conditioned ventricles.

CONCLUSIONS
Langendorff-perfused guinea-pig ventricles, when treated with DPI 201-106 plus veratridine in combination, exhibit drastic QTc prolongation and bradycardia. These conditions are believed to be the most important and dangerous prerequisites for the development of torsades de pointes. The present model may be useful in further experimental investigation of the not well understood torsades de pointes arrhythmia complex. This is your great chance – buy flovent inhaler to take full advantage of best quality drugs.

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