Tag Archives: circadian variation

Circadian Variation of Bronchial Caliber and Antigen-induced Late Asthmatic Response: Conclusion

Two patients (patients 1 and 6) had wider circadian FEVj variation, with marked decrement at 2 am, than that seen in the other 4 patients during the control period. Nevertheless, the decrement in the FEVj at 2 am in the … Continue reading

Circadian Variation of Bronchial Caliber and Antigen-induced Late Asthmatic Response: Discussion

Furthermore, the maximum bronchial obstruction following antigen inhalation occurred between 10 pm and 6 am whenever the bronchial challenge was made. In particular, bronchial obstruction at 2 am was maximum or near maximum in both challenge studies. Antigen inhalation and … Continue reading

Circadian Variation of Bronchial Caliber and Antigen-induced Late Asthmatic Response: Results

Information describing each patient involved in the study is given in Figure 1 and Table 2. The FEV, immediately before the house-dust inhalation was within 10 percent of the value at the beginning of the study, at 10 am in … Continue reading

Circadian Variation of Bronchial Caliber and Antigen-induced Late Asthmatic Response: Design of Study

Although some patients received oral bronchodilators as needed (a combination of short-acting salbutamol [2 mg] and aminophylline [100 mg]), and 2 patients received inhaled cromolyn sodium 3 times per day and 4 received oral ketotifen twice per day regularly, all … Continue reading

Circadian Variation of Bronchial Caliber and Antigen-induced Late Asthmatic Response: Patients and Methods

Both the late asthmatic response (LAR) and nocturnal bronchial obstruction are based on airway inflammation; however, definite airway inflammation following antigen inhalation does not necessarily cause LAR in anesthetized animals with acquired sensitization, and airway inflammation alone cannot explain the … Continue reading