Tag: DPI 201-106

Conditioning guinea-pig hearts in vitro for torsade de pointes arrhythmias (part 9)

While conditioning the ventricles for torsades de pointes by inducing bradycardia and prolonging QTc, favouring triggered activity , no spontaneous arrhythmias were observed. Interestingly, at the end of the experiments electrical stimulation during T wave of these conditioned ventricles induced transient arrhythmias, preliminarily demonstrating the sensitivity of the model. Experiments are in progress to define […]

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Conditioning guinea-pig hearts in vitro for torsade de pointes arrhythmias (part 7)

For the pharmacological induction of substantial QTc prolongation we employed the sodium channel ligands DPI 201-106 and veratridine in combination. Both veratridine and DPI 201-106 inhibit cardiac sodium channel inactivation and hence prolong action potential duration, as do various other compounds . It was previously demonstrated that veratridine, with an affinity to binding site II […]

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Conditioning guinea-pig hearts in vitro for torsade de pointes arrhythmias (part 6)

Conditioning guinea-pig hearts in vitro for torsade de pointes arrhythmias

No toxic effects and no spontaneous arrhythmias were recorded because all preparations remained in a stable condition throughout the experiment. At the end of the experiments ventricles treated with DPI 201-106 plus veratridine responded to electrical stimulation with torsade de pointes-like episodes (Figure 3). This observation should be taken as a preliminary indication for the […]

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